Endogenous Regenerative Technology
ENDORET® Technology - WHAT IS IT?
ENDORET® is a biomedical technology aimed at stimulating tissue regeneration by applying autologous proteins. Hundreds of endogenous proteins affect the tissue repair processes, including angiogenesis, chemotaxis and cell proliferation. No exogenic agent can effectively govern all these processes. (1)
ENDORET® technology provides the necessary means for obtaining plasma rich in growth factors from whole blood.
Advantages of ENDORET®
ENDORET® is the technology with the most experience on the market in the development of specific protocols for tissue regeneration, a pioneering technology manufactured exclusively by BTI® Biotechnology Institute.
OPTIMUM CONCENTRATION OF PLATELETS
The right concentration of platelets affects the final efficacy.
(2) (40)
FORMULATION FREE OF LEUKOCYTES
The inclusion of leukocytes increases the pain and inflammation
(41) and accelerates the deterioration of the fibrin.
(42)
CONTROLLED ACTIVATION
Enables the formation of the fibrin matrix in situ and the gradual release of growth factors, maintaining its efficacy over time.
(4) (43)
AUTOLOGOUS
It is made from the patient’s own blood, so there are no known adverse effects.
(44)
REPRODUCIBLE
The protocol for the preparation process and its clinical application is strictly defined and tested.
VERSATILE
4 preparations that can adapt the product to the clinical needs.
(15) (45)
Proteins and Autologous Matrix
GROWTH FACTORS
ENDORET® stimulates tissue regeneration due to enrichment with growth factors, acting as a biological system.
(2)
FIBRIN MEMBRANE
Enables the balanced and gradual release of a large number of molecules, including growth factors and other proteins.
(3) (4) (5)
Quantification of the increase in VEGF (vascular endothelial growth factor) and PDGF (platelet derived growth factor)
Regenerative Potential
- Promoting angiogenesis (A). (6)
- Stimulating cell migration (B). (7)
- Increasing the proliferation (B). (7) (8) (9)
- Decreasing inflammation and pain (C). (10) (11) (12)
- Stimulating autocrine and paracrine secretion of growth factors (B). (7) (8) (9)
(A) Pre-clinical study
(B) In vitro study
(C) Clinical study
ENDORET® accelerates cell migration for regenerative purposes (7) (8)
ENDORET® technology reduces the tissue repair time in clinical trials. (13) (14)
Response of the tissue
Versatile Applications
The versatility of the ENDORET® technology allows for its use in different clinical applications. (15)
Liquid
Clot
Autologous bone graft
Fibrin Membrane
Safety
- Autologous product, there are no incompatibilities nor risk of rejection.
- All the formulations of ENDORET® have a bacteriostatic effect, especially during the 4 hours after application (in vitro studies). (16) (17) (18)
- More than 700,000 patients have been treated in more than 20 countries, without any adverse effects being reported.
